The Mass. Caregiving Initiative will host speakers from the MA Executive Office of Elder Affairs, SecureSeniorConnections, Greater Springfield Senior Services, Babson, and AARP MA as we explore the downstream health consequences of social isolation and how the innovation ecosystem is responding to address this long-standing crisis. Isolation among older adults in the United States was identified as a looming public health crisis before “social distancing” was ever part of the public vernacular. In recent years there has been stronger and stronger evidence drawing a connection between isolation in the 50+ population and all-cause mortality, increased risk of dementia, and increased risk of heart disease. Tackling a challenge of this magnitude necessitates a broadened definition of innovation – to include innovators in technology, public policy, community support, and healthcare who can address the unique factors that contribute to isolation in this age group.